Harold and Kumar run into a serious problem when one of the people on their airplane mistakenly believes that the men are terrorists. The two are taken off the plane, interrogated and sent to Guantanamo Bay.
While there, the two forge a plan with two other prisoners to escape the prison. They use a refugee boat in Cuba to make their way to Miami. The two contact a friend, and they are able to use his car and decide that the only person who can help them is Vanessa's finance Colton. He comes from a wealthy family with government and political connections, so they believe he can help them clear their names.
Colton views Kumar as a threat to his impending marriage to Vanessa. He decides to call and have the men returned to Guantanamo Bay. While on the airplane, the men try to subdue the men guarding them with mace. Agent Beecher sees Agent Fox and wants to release the men. A fight ensues, and the men use a parachute and crash into George W. Bush's roof, and he decides to issue them a presidential pardon.