The story follows a group of interns and nurses working at St. Albert's, the worst teaching hospital in Canada, as they try to deal with work and relationship stress. Run by administrator Dr. Cyrill Kipp, the hospital only manages to stay open because Kipp sells the hospital's equipment on the black market. During on-the-job training taught by Dr. Whiteside, interns brave blood, vomit and exploding colostomy bags. The students include the nerdy Mike Bonnert, whose parents are physicians, Mitzi, who works as a stripper to pay her way through school, and the innocent Christine Lee who loses her inhibitions when intoxicated. Mike discovers that his girlfriend, Mitzi, gave a blowjob to one of his friends. They begin to fight in the morgue, using human organs as weapons. They are caught and expelled from St. Albert's. But when a 76-car pile up occurs, they return to ER to help the patients. One patient, who was saved in an emergency surgery, was billionaire, and saves the hospital from going bankrupt.