Me, Natalie is a romantic comedy about a female struggling with self-esteem. As a young girl, she never felt pretty. This emotion is further strengthened by a less than supportive father. During adulthood, her choices reflect this inner struggle. From her residence to companionship, she murks around in mire. This scenario, of course, leads to trouble. There's a point in this film in which the main character, Natalie, discovers a secret that ushers in personal crisis. She has to make a difficult decision.