The story of The Bride with the White Hair 2 focuses on a witch who became possessed when she mastered an ancient and powerful skill, which made her evil and destroy all eight clans. The remaining clans left alive decides to lend their support to a man named Zhou Yihang, who plans in battling the witch. Unfortunately, he was forced to back out of the fight, to keep away from the ongoing dispute with the remaining clans who wanted power.
However, during Feng Junjie and Yu Qin's wedding night, the Witch arrived and murdered all of their guests and kidnapped the bride, who was a descendant of the two major clans, along with her husband.
As Junjie tries to go after the witch who took his wife, the Witch takes Yu Qin to Yuanyuan Paradise.