Rome, March 2003. Attilio de Giovanni (Roberto Benigni), a comical but talented literature professor and the divorced father of two teenage girls, is hopelessly in love with Vittoria (Nicoletta Braschi, Benigni's wife in real life), a writer who is the subject of a recurring dream, featuring a surreal wedding ceremony with poetry verses in the background. Attilio's strenuous courtship is unsuccessful, yet he does not lose hope, despite the fact that Vittoria obviously does not share the same feelings.
Vittoria leaves to go to Iraq to write the biography of the poet Fuad (Jean Reno), a close friend of Attilio who is returning to his country after 18 years in exile in France. Vittoria is wounded during the Iraq War and Attilio manages to reach Baghdad with the intention of saving her life. He finds Vittoria in an Iraqi hospital lying in a coma; like thousands of Iraqis, she is in danger of dying from lack of medicine. Fuad directs Attilio to an old Iraqi pharmacist, who suggests ancient treatments that keep her alive. Attilio then runs the risk of going to the Italian Red Cross HQ in Iraq, obtains medical supplies by posing as a doctor, then brings medicines back to Baghdad. The medical supplies enable Vittoria to make a complete recovery, but when Attilio goes to Fuad's house to tell him about this triumph over adversity, he finds that Fuad has hanged himself. Fuad had earlier had a short soliloquy on how "his eyes no longer...", but Attilio had not picked up on because he was frantically trying to make the glycerine mixture to save Vittoria. Just before Vittoria emerges from her coma, Attilio is captured by the U.S. Military and is mistaken for an Iraqi insurgent.
In the final scenes it is revealed that Vittoria is Attilio's wife. They are obviously separated in this story, perhaps because of his tumultuous over-abundant energy and insane diversions, (along with earlier transgressions with another woman). Several times we see Attilio in awkward visits to Vittoria and their children, and obviously he is still hopelessly in love. (He proves this in the most extreme way- finding her and somehow managing to save her life in war-torn Iraq.) In the final scene of the film, even though Attilio won't admit that he is the "wonderful stranger who saved her", Vittoria suddenly recognizes his familiar way of brushing her cheek in the same manner that "the stranger" had touched her when she was lying unconscious in the hospital, and the way her necklace (that he took from her in Iraq, for safekeeping) dangling from his neck touches her face.
