The film opens with news clips giving the back story of a world in turmoil. The fourth G.X. Bush administration has resulted in the disbanding of Congress, and wars with nearly every other country on the planet. The gross mishandling of foreign affairs has led to too many wars and not enough soldiers. This is where a government experiment to create a serum to inject dead soldiers and turn them into reanimated fighters to be sent back out on the front lines.
Naturally the virus spreads to the workers in the research facility, and is in danger of becoming an epidemic of global proportions. The Z Squad is then formed of Marines with the sole mission of containing the virus and preventing the lab workers from escaping and spreading the virus to the general population.
When this elite team descend on the original research ab, they wipe out the threat and leave it behind. One of the soldiers is bitten, but manages to escape without anyone knowing about it. He leaves and hides near an underground strip club called Rhino. All public nudity is outlawed in this version of the future, so strip clubs had to hide to avoid prosecution. He dies in the alley, and is reanimated as a zombie, then enters the club.
A new girl named Jessy has just started work at the club in order to save money for her grandmother's operation, and is introduced to the star dancer of the club, Kat, to learn the ropes. As Kat takes the stage for her dance she is attacked and bitten by the Marine. Ian, the club owner, is worried that he will lose money if his best girl is dead, so he lets her back on stage as a zombie stripper. She turns out to be more popular and a better dancer as a zombie than she was before.
The other girls then start losing their customers to the zombie stripper and are faced with a choice to either become zombies themselves to compete or leave the business. One girl does it just for fun, but they all make the decision to continue as zombie strippers. They are kept locked in cages in the club basement by the club owner, since they have a tendency to kill their private dance customers. They manage to escape and overrun the club. The humans that are left in the club fight for their lives just as the Z Squad breaks in and takes charge of the situation.
The tale ends by revealing the Bush administration let the zombies loose in order to distract the public from the severe mis-management of all their policies and the economy.
Porn star Jenna Jameson jumps aboard the Romney bus by announcing her support for his presidential candidacy, because she's rich, and probably hasn't done a lick of research.