Since the movie's characters are animated but still have voices that are used from actual actors and actresses. The movies stars are from Hollywood become the characters: Claire Redfield with the voice of Alyson Court, Leon S. Kennedy with voice Paul Mercier, and Angela Miller with voice of Laura Baily. The crews of characters are special force members that are called into action to bring down a mutant monster caused from the chemical and biological viruses that are released in Harvardville. Their goal is to prevent history from repeating itself from another incident.
The main plot of the movie takes place at the Harvardville Airport where the facility is under attack from a person that is seeking revenge and the release the biological T-virus and G-virus that affects the human body. A terror event takes place in one of the airport terminals causing a lock down of the airport. The marines that are dispatched to evacuate the Harvardville area actually become affected with one of the viruses. The goal of the characters is to try to prevent another biological incident like the one at Raccoon Center and protect the human race. The T-virus and G-virus affects the human body by making them into zombie creatures. They are to stop the virus from being released into the major United State Cities.