The Mayo Clinic Guide to Pain Relief Season 1 Episode 3 Common Causes of Chronic Pain

Many conditions can lead to chronic pain, but one more recently discovered cause is central sensitization. This syndrome is caused by dysregulation of the spinal cord, the brain's thalamus, hypothalamus, and amygdala, and alterations in how pain is experienced. Central sensitization is thought to be the underlying cause of fibromyalgia, chronic fatigue syndrome, and more.