Herbert West has discovered how to bring the dead back to life. His discoveries are too outrageous for the university he attends in Sweden so he enrolls in Miskatonic University in New England. Fellow medical student Dan Cain slowly comes to discover that West can reanimate the dead with a special serum. The evil Dr. Carl Hill discovers West's secret as well after he operates on the dean of the university. The operation reveals the dean was killed and brought back to life. Hill is eventually killed by decapitation and the head and body are both reanimated. The enraged Hill now plots revenge.