Least Among Saints tells the tale of Anthony Papazian, a former Marine who has recently completed a deployment overseas and has just now returned home to Arizona. After being in the war, he now suffers from PTSD. To further add to his troubles, his ex-wife, Jenny won't allow him to go anywhere near her, evident by the fact that she placed a restraining order on him. Dealing with his troubles, Papazian befriends his neighbor Cheryl, whom he is doing what he can to protect her from her abusive boyfriend. Papazian ends up befriending Cheryl's son who looks up to him, and shortly after a tragic event, the two grow even closer.