After the fiasco Harrigan is ordered to work with government agent Keyes (Gary Busey), whose cover is that he's investigating the cartels. In the course of his investigation Harrigan talks with a Jamaican drug lord and voodoo practitioner named King Willie. Willie casts the bones, and tells Harrigan the killer is from the spirit world, and is not human. Soon after Harrigan and his team disobey orders to wait for Keyes and instead go into a gang stronghold, finding they've been killed and skinned. The detectives are then shut out of the investigation and Keyes and his men take over.
During an unrelated attempt to stop a subway mugging, the Predator attacks cops on Harrigan's team, killing one but leaving the other when it sees she's pregnant with its thermal vision. Harrigan hunts the creature down, but finds Keyes and his team, who are really there to capture the predator and take its technology. The team moves in, but are killed by the predator. It escapes, chased by Harrigan over rooftops and through apartment buildings until he follows it back to its lair; a hidden predator ship. Harrigan kills it, and the other predators give him a trophy of an old flintlock pistol. Harrigan leaves the ship, and it takes off.