The sequel to the 1987 film Predator, set in Los Angeles, is a story about the universe hopping hunters coming to planet Earth and treating it as their own personal game reserve. When police officer Lieutenant Michael Harrigan (Danny Glover) catches wind of it though, a showdown is just a matter of time. The movie, set in 1997, opens during an intense heat wave and major gang wars between Columbian drug lords. Harrigan gets involved in a major firefight, chasing members of the cartel back into their hideout. Before the police can get inside though, the Predator slaughters the cartel members. Harrigan catches a glimpse of it, but writes it off as a trick of the light.
After the fiasco Harrigan is ordered to work with government agent Keyes (Gary Busey), whose cover is that he's investigating the cartels. In the course of his investigation Harrigan talks with a Jamaican drug lord and voodoo practitioner named King Willie. Willie casts the bones, and tells Harrigan the killer is from the spirit world, and is not human. Soon after Harrigan and his team disobey orders to wait for Keyes and instead go into a gang stronghold, finding they've been killed and skinned. The detectives are then shut out of the investigation and Keyes and his men take over.
During an unrelated attempt to stop a subway mugging, the Predator attacks cops on Harrigan's team, killing one but leaving the other when it sees she's pregnant with its thermal vision. Harrigan hunts the creature down, but finds Keyes and his team, who are really there to capture the predator and take its technology. The team moves in, but are killed by the predator. It escapes, chased by Harrigan over rooftops and through apartment buildings until he follows it back to its lair; a hidden predator ship. Harrigan kills it, and the other predators give him a trophy of an old flintlock pistol. Harrigan leaves the ship, and it takes off.