Ep 28. Infrared Spectroscopy

Foundations of Organic Chemistry season 1 episode 28, titled "Infrared Spectroscopy," is an in-depth exploration of the essential techniques and principles used in modern organic chemistry. The episode focuses on the role of infrared (IR) spectroscopy in the characterization and identification of organic molecules.

The hosts begin by discussing the fundamental properties of light, including wavelength, frequency, and energy. They explain how IR spectroscopy uses these properties to identify the different functional groups present in an organic molecule. They also introduce the concept of a spectrum and how it corresponds to the unique vibrational modes of the molecule.

The episode goes on to explore the instrumentation used in IR spectroscopy, specifically Fourier transform infrared (FTIR) spectroscopy. The hosts discuss how FTIR spectroscopy works, including the use of a Michelson interferometer to produce an interferogram. They also discuss how this interferogram is transformed into a spectrum using a Fourier transform.

The hosts then delve into the interpretation of IR spectra. They explain how characteristic peaks in the spectrum correspond to different functional groups, such as carbonyls, alcohols, and amines. They also discuss how the position and intensity of these peaks can provide information about the environment in which the functional group is located.

Throughout the episode, the hosts provide numerous examples of how IR spectroscopy is used in organic chemistry research and industry. They show how IR spectroscopy can be used to identify unknown compounds, monitor chemical reactions, and analyze the composition of a sample. They also discuss some of the limitations of IR spectroscopy, such as its inability to distinguish between stereoisomers.

The episode concludes with a discussion of some advanced applications of IR spectroscopy, including attenuated total reflection (ATR) spectroscopy and two-dimensional (2D) IR spectroscopy. The hosts explain how these techniques can provide even more detailed information about the structure and dynamics of organic molecules.

Overall, "Infrared Spectroscopy" is a comprehensive and informative episode that provides a thorough introduction to the principles and practices of IR spectroscopy in organic chemistry. It is a must-watch for any student or researcher looking to deepen their understanding of this essential technique.