Frank Pierce (Cage), is a paramedic working the graveyard shift in Hell's Kitchen, Manhattan, a neighborhood in New York City, during the early-90s. It takes place over the course of three nights, each night pairing Pierce with a different partner (Goodman, Rhames, and Sizemore). Complaining of burn out, Pierce suffers from insomnia and begins having visions of a young girl named Rose who died while under his care. Once called Father Frank for his ability to save lives, Pierce starts to fear that he will soon face another life he cannot save, and begins attempting to get fired as his visions of Rose become more frequent. Soon, Pierce bonds with Mary (Arquette), the daughter of a heart attack victim whom he had previously saved, and who visits her father regularly at the hospital. Mary talks to Frank about her compassion toward helping others, which is shown contrasting Frank's feelings of burnout. It is through Mary that Frank is able to reconcile his feelings about Rose, and in the end, sleep.