Paul Zadzig, a once-fine car salesman, is in the midst of a downhill slide in life, and is further depressed when his wife leaves him. He tries to burn his house down in an attempted suicide but is stopped by one of his co-workers. The next day after a bad confrontation with his boss, he again attempts suicide but is interrupted by a visit from three Arhuaco shamans from the mountains of Colombia.
The shamans' guide explains that the spiritual leaders have been sent to California to find "The Chosen One," who turns to be Paul. Though the shamans believe Paul is the one that will save the world, Paul explains that he doesn't even have minimal control over his own life.
Paul tries to send the shamans and their guide back to Colombia, but they return to his house in the middle of a visit from his highly dysfunctional mother and gay Buddhist-monk brother Neal.