Watch TRIGUN STAMPEDE

Everyone's fate hangs in the balance as the clash between Vash and Knives grows more intense.

Meryl runs into Nicholas and scolds him for leaving Vash. Vash is trapped in a device that uses him to access a dimension where the original Plant is thought to exist. Knives alters Vash's memories until only his first memory with Rem remains.

Meryl and Roberto are brought to Jurai, where Zazie asks them whether humans or Plants should survive. Conrad reveals that he is trying to create humans with Plant abilities, but to complete his research he needs to use a living Independent Plant.

Conrad visits a Plant facility with Knives, who declares that he will kill all humans in order to protect the Plants that don't have free will. Knives orders Vash to kill Luida but Vash refuses, and his Plant power activates to protect her.

After crashing on Noman's Land long ago, Vash wanders the desert until he's taken in by the Mothership 3's survey team. Vash is isolated from everyone else until earning their acceptance, but they discover his secret: he isn't the only Independent Plant.

Nicholas and Livio engage in an intense battle until Vash stops Nicholas from finishing Livio off. Nicholas notices that Livio's dormant memories have started to show through in his behavior, but it's too late for Nicholas to save Livio.

Vash and Nicholas part ways with the two reporters and board a Sandsteamer bound for Jurai. Awaiting them there is an assassin named Livio, who grew up in the same orphanage as Nicholas and admired him as an older brother figure.

When Vash stops at a windmill town in the red desert area, he's attacked by Monev, the shadow that remains of Rolo. Vash had been unable to save Rolo from Conrad's experiments when he was a child, so Rolo has immense hatred for both Vash and Conrad.

Vash, Meryl and Roberto head for Jurai in pursuit of Knives. During their trek through the desert, they're joined by Nicholas, who calls himself an undertaker. But when they stop at a charging station, they get swallowed by a giant sandworm!

A bomber attacks the town of Jeneorarock while they are celebrating the restoration of their Plant. Vash tries to disarm the bombs, but his twin brother, Knives, shows up to steal the Plant. Vash confronts Knives, but is overwhelmed by his strength.

Vash is in danger again now that ordinary townsfolk who have heard about the bounty are after him. As Vash tries to leave town, he runs into a family of heinous criminals who have broken out of prison and are now in a race to claim the bounty on his head.

Veteran reporter Roberto and rookie Meryl find themselves helping Vash the Stampede, an infamous thief with a bounty of six million double-dollars on his head.