The exploration team investigates a pyramid that Weyland Industries picked up on its satellites and they discover numerous writings and symbols on the walls. As they uncover more about the structure, they learn more about its origins. As more and more team members are trapped and killed, the team realizes that the structure is a hunting ground for the Predators and that the humans were being used to breed their prey: the Aliens. Caught in the middle of a war, the remaining survivor Alexa picks a side to prevent the war from affecting people elsewhere in the world. This serves as a twist that fans of neither franchise would expect, since it is out of character for Predators to team up with their prey (as seen in the original 1987 Predator film).
Utilizing special effects and incorporating an original story not expected from fans of the Alien and Predator franchises, the film serves as both a unique science fiction experience and an interesting addition to the two sagas. Since the plots from both sagas are unused, the film can be watched by anyone who just wants to enjoy a science-fiction film.