Biochemistry and Molecular Biology: How Life Works Season 1 Episode 6 Hemoglobin Function Follows Structure

In season 1 episode 6 of Biochemistry and Molecular Biology: How Life Works, viewers are taken on a journey through the structure and function of hemoglobin, the protein responsible for transporting oxygen in our blood. The episode begins with an overview of the history behind the discovery of hemoglobin, highlighting the work of scientists such as Joseph Priestley and Otto Warburg.

From there, the program delves into the nitty-gritty details of hemoglobin's structure. Viewers learn about the four subunits that make up the protein, as well as the heme group that gives hemoglobin its characteristic red color. Through the use of computer-generated models, the show illustrates how the shape of the protein is crucial to its function.

The episode then moves on to a discussion of how oxygen binds to hemoglobin, a process known as oxygenation. Viewers learn about the role of heme in this process, as well as how the shape of the protein changes to accommodate the binding of oxygen molecules. The program also touches on the phenomenon of cooperativity, in which the binding of one molecule of oxygen increases the likelihood that additional molecules will bind to the protein.

Next, the episode explores how hemoglobin releases oxygen once it reaches the body's tissues. Viewers learn about the role of pH and carbon dioxide levels in promoting the release of oxygen, as well as the importance of the shape of the protein in this process. The program also touches on the phenomenon of Bohr shifts, in which changes in pH affect the affinity of hemoglobin for oxygen.

The episode concludes with a discussion of some of the ways that hemoglobin can go wrong. Viewers learn about the genetic mutations that can lead to conditions such as sickle cell anemia, as well as the effects of carbon monoxide poisoning on hemoglobin function. The program also touches on the use of hemoglobin as a therapeutic agent, highlighting the development of artificial blood substitutes.

Overall, season 1 episode 6 of Biochemistry and Molecular Biology: How Life Works provides a comprehensive overview of the structure and function of hemoglobin. Through the use of computer-generated models and easy-to-follow explanations, the program makes complex scientific concepts accessible to viewers of all backgrounds. Whether you're a student of biology or simply curious about the inner workings of the human body, this episode is sure to be a fascinating and informative watch.