Watch RED 2

Ex-CIA agent Frank Moses is trying to adjust to a normal, suburban life with his girlfriend Sarah Ross when his former partner, Marvin Boggs, approaches him at a big box store. Boggs claims there are people after him and asks for Moses's help. Moses declines, thinking it is more of Boggs's paranoid delusions. Shortly after the meeting, Boggs's car is blown up in the parking lot.

Following the funeral, Moses is taken to a CIA facility to be interrogated. But another agent, Frank Horton, shows up and tries to kill Moses. Moses kills most of Horton's crew and escapes with the help of Boggs, who had faked his death. Boggs explains to Moses they are being hunted in connection with a Cold War operation known as Nightshade.

Moses and Boggs get Sarah and the trio head to Paris to track down a lead on Nightshade, with the elite assassin Han chasing them. Once in Paris, they are confronted by Russian secret agent Katya, Moses's ex-girlfriend. With her help, they find a French weapons dealer known as The Frog, who leads the four on a car chase throughout the city before he is caught. Moses and company then find documents in The Frog's possession that provide them with information on Nightshade and the man behind it, a brilliant physicist named Edward Bailey. With the help of MI6 assassin Victoria Winslow, they break into the asylum where Bailey has been held for more than 30 years and free him.

Bailey tells the group exactly what Nightshade is and where it is located. They must travel to both Moscow and London to secure Nightshade, again with the assassin Han still on their tail. This leads to a series of car chases and gun battles as Moses and the others attempt to save the day.