Conan Season 2015 Episode 149 Cindy Crawford, Chris D'Elia, Nick Lowe and Los Straitjackets

The episode opens with host Conan O'Brien introducing his guests for the night, Cindy Crawford, Chris D'Elia, Nick Lowe, and Los Straitjackets. Crawford, the supermodel of the 90s, talks about her journey through the fashion industry, her passion for furniture designing, and her newly released book "Becoming". Crawford speaks about her lifestyle brand called "Meaningful Beauty" which aims to provide skincare products that are suitable for all skin types. With her charming personality, she speaks candidly about her marriage with Rande Gerber, her two children, and how her family stays grounded amidst all their fame.

Comedian Chris D'Elia joins Conan on the couch to discuss his role in the sitcom "Undateable" and his upcoming comedy special on Netflix called "Man on Fire". D'Elia also talks about his love for music, specifically hip-hop, and does an entertaining impression of rapper Drake. The conversation turns to D'Elia's online presence, and how he enjoys interacting with his fans on Twitter.

Next up, the audience is treated to a musical performance by legendary singer-songwriter Nick Lowe and his accompanying band Los Straitjackets. Lowe, now in his 70s, shows no sign of slowing down as he belts out his hit song "Cruel to be Kind" to thunderous applause.

After the performance, Conan invites Lowe to the couch for a chat. The two discuss the origins of Lowe's music career, his influences, and his songwriting process. Lowe talks about his love for rock music, and how he never had any intention of becoming a mainstream artist. Lowe's witty sense of humor keeps the audience entertained as he talks about his experiences in the music industry.

The show closes with Conan thanking his guests for appearing and promoting their respective projects. The episode leaves the audience entertained, informed, and inspired by the stories of the evening's guests.