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It's Thanksgiving, and the team discover they have little to be thankful for in their personal lives. Meanwhile, House takes on the illness of a brilliant physicist who has rejected his intellect to work as a courier.

While Cuddy deals with her personal relationships, House is finally reinstated and takes on the case of a porn star with eye pain.

After a wild night out, a teenage girl is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill, and as her condition worsens, becomes unable to distinguish fact from fiction. Meanwhile, Cuddy and Wilson attend a medical conference for pharmacology and public policy. House tags along, planning to use the outing as an opportunity to push a personal agenda, but things don't go as expected.

A dying patient insists that he has the same disease affecting his heart that killed his father and grandfather at the age of 40. Meanwhile, House discovers that he has a hearing problem while trying to duck student rounds.

A rich businessman brings his son, who's suffering from stomach pain, to Princeton Plainsboro, and believes he's a victim of his wealthy position and success.

House's team struggles with an African politician who falls ill and decide if they want to help him after he's charged for crimes against humanity in his country.

House returns to Princeton Plainsboro, announcing he will make big changes in his life. Meanwhile, House's team can't diagnose a new patient who's obsessed with posting each and every one of his symptoms over the Internet.

House engages in a battle of wits and wills against the attending physician in charge of his detox program. When he starts to lose, House resorts to blackmail to gain the upper hand.

House takes on a case of a patient with two different personalities as a result of having the left and right part of the brain operating independently.

While House tries to cope with his insomnia, he takes on the case of a ballerina whose skin begins to fall off after treatment following the collapse of her lungs during a performance.

A deaf 14-year old wrestler suffers from hearing problems during a match, but his mother refuses to okay cochlear implants. Meanwhile, House's insomnia proves a curse... and a blessing.

Cameron postpones her vacation with Chase in order to ask House to accept the case of an environmental radical who collapsed at a protest with unexplainable symptoms. Although suspicious of her motives, House agrees. Since she pushed him to take the case so emphatically, House forces Cameron to take the lead and run many of the tests on the patient. Meanwhile, House is unsure of Wilson’s new healthy diet.

Charlotte, an older woman who has spent the last six months taking care of her dying husband Eddie, is rushed to Princeton Plainsboro after collapsing from respiratory failure. The couple becomes a double mystery for the team when Eddie begins to improve as Charlotte’s condition worsens. The previously unthinkable becomes real when it seems that Charlotte will die before Eddie, and the team will be forced to make a difficult decision.

Lee, a man who awakens in New York after a bicycle accident unable to move or communicate in any way. House, himself injured in a motorcycle mishap, occupies the hospital bed next to Lee and quickly annoys the doctors treating them both by insisting that Lee has “locked-in” syndrome. After House gets Lee transferred to Princeton Plainsboro, the team is on the case to try to “unlock” him. Meanwhile, Wilson suspects House is hiding something when he refuses to divulge why he was in New York.

Nursing-home worker Morgan fakes sick to get House's attention after the home’s pet cat sleeps next to her. It seems that the cat only pays a visit to people if they are about to die – and does so with alarming accuracy. While House dismisses Morgan as a nut job, he is intrigued by her theory on the kiss-of-death cat, and sets out to disprove it. When Morgan falls seriously ill, he and the team are forced to get to the bottom of both mysteries.

House and the team treat a patient who speaks his mind uncontrollably; House thinks taub amd wilson are keeping something from him ( can't wait tosee this episode!!)

The team encounters a teenage boy who collapsed from severe pelvic pain after playing basketball. Tests reveal the boy has genetic mosaicism, or both male and female DNA, and the boy’s parents inform House and the team that the boy is unaware of his condition. They consciously chose a gender for him when he was born and raised him accordingly, never telling him about his unique condition. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision. Meanwhile, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nicely. When they discover the shocking answer, they must face the prospect that House may be changed forever.

When a priest who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep, he is admitted to the ER. House takes on the case as a distraction for the team while he confronts Foreman and Thirteen about their relationship. The team soon learns the priest had been involved in a molestation scandal that caused him to lose his faith. However, just as they are about to dismiss his case, the patient’s condition takes a drastic turn for the worse, and House grapples with his past and his beliefs.

The team take on the case of a cancer researcher who gave up her career to pursue personal happiness. While House's staff question how much happiness they've found, Cuddy metes out some poetic justice to House, and Thirteen begins suffering reactions to the Huntington's trials.

House suspects a Special Education teacher of becoming ill from her inherent goodness. Meanwhile, Cameron takes on some of Cuddy's duties and finds herself up against House. And Foreman has to make a decision when he learns that Thirteen is receiving the placebo in the Huntington's clinical trials.

Thirteen receives treatment by Foreman while taking part in his clinical trial on Huntington's Disease.

House and the team diagnose a bullied girl who collapses at her school's holiday pageant. Meanwhile, House gives one of his patients a gift, Cuddy gets a gift, the team tries to figure out who gave House a special gift, and Foreman learns a lesson from Thirteen during the Huntington's drug trials.

House and the team try to help a fitness guru who collapsed during an infomercial filming. Foreman conducts drug trials for Huntington's and Thirteen participates: Cuddy moves into House's office while her's is repaired, and Kutner runs an Internet advice clinic using House's name.

Episode 9 of Season 5 on House, entitled "Last Resort," airs on FOX Tuesday November 25th, 2008. The summary is a man takes over Cuddy's office and holds House, Thirteen, and several patients hostage. His demand? A diagnosis. The man forces Thirteen to act as a guinea pig for his treatments and House has to end the standoff before a SWAT team opens fire.

While Foreman takes on a pediatric case on his own, the rest of the team deals with a 16-year-old factory manager and emancipated minor who collapses at work. When Foreman's patient takes a turn for the worse, he's forced to question whether he can deal with the situation on his own, or if he needs House's help.

The team must treat an agoraphobic who refuses to leave his house, and have to work around Cuddy, who is less than thrilled at having hospital equipment relocated. Meanwhile, House is plagued by an itch, and Cameron and Chase have relationship issues.

The team takes on the case of a dreary middle-aged man who has been experiencing unexplained recurring blackouts and time lapses. With possible diagnoses ranging from a stroke to a concussion to toxins from the consumer products he has been testing for work, they soon find that the man, who is raising his 12-year-old daughter on his own, has been experiencing intense sleepwalking spells. As the team tries to find out what he could be doing during his sleep to make himself sick, his condition continues to deteriorate and his daughter also falls gravely ill. Meanwhile, House finds out Cuddy is going to adopt a baby that is due in two weeks. But when Cuddy meets the birth mother in person and notices a strange rash on her arm, Cuddy brings the mother to Princeton-Plainsboro where her condition worsens. Cuddy must take on the case as both a doctor and a potential mother, and she and the team are faced with a heart-wrenching decision that could risk either the birth mother's or the baby's life.

Thirteen's female lover has a seizure after a night of partying and she takes the woman to the hospital. It turns out the woman has a long-standing medical condition and slept with Thirteen to get House. Meanwhile, Foreman confronts Thirteen about her destructive lifestyle and House continues to have Lucas spy on Wilson.

House's friends and teammates coerce him going into his father's funeral. However, en route they get the case of a young Chinese girl and House must participate in the differential... until his cell phone goes dead at a critical moment.

House and his team diagnose a struggling artist dying of an unknown disease, whose illness affects not only his career and his relationship, but his work.

The team deals with an organ donors whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.

After Wilson threatens to resign House thinks of anything to try and keep him at the hospital, and to keep their friendship alive. Meanwhile, the team treat an executive assistant with a Class A personality who reminds Thirteen of herself.

House is still suffering from injuries resulting from the bus crash, and struggles through his amnesia to recall a key symptom that he saw an associate suffering from, before it's too late.

A bus accident has left House with a head injury along with dozens of passenger with injuries. Although he is dazed, House has flashbacks where he can recall one passenger having had the signs of a deadly illness, but can't remember who it was or what he saw that clued him in.

After observing one of the actors from his favorite soap opera "Prescription Passion" showing symptoms of a serious medical condition while on TV, he decides to take matters into his own hands. But both the actor and House's own team believe there is nothing wrong with him and dismiss Dr. House's assessment.

House is intrigued by a patient who is nice... constantly. Believing he's suffering from some illness, House orders a series of tests. Meanwhile, Amber and House haggle over spending time with Wilson, the team discover a shocking secret about their boss, and Cuddy tries to get House to complete his performance reviews.

A bride collapses during her Hasidic Jewish wedding, but her husband isn't convinced by House's bedside manner. House is occupied dealing with the shock brought on when he discovers who Wilson's new girlfriend is.

House and his team must diagnose an ailing researcher by webcam, as she's iced in at an Antarctic research base with a limited amount of resources. Meanwhile, House is determined to find out who it is that Wilson is now dating.

A mother's hands are paralyzed during an indoor rock-wall climbing incident, causing her daughter to injure herself. At the hospital, her condition worsens and House and his newly-assembled team race to find a cure. Meanwhile, House decides to add a few twists to the season's Secret Santa gift exchange.

When Cuddy puts the pressure on House to choose the final members of his team, House deliberately assigns the candidates to a particularly challenging case an uncooperative, over-the-hill former punk rock star with a history of drug abuse and civil disobedience. House informs the candidates their potential future depends on correctly diagnosing the patient. As the candidates race to find out if the patient is ailing due to drug abuse, an underlying disease or an unknown condition, House keeps a running tally of their efforts, making a few arbitrary point deductions along the way. Meanwhile, Wilson informs a former patient whom he had previously diagnosed with terminal cancer that he is going to live, and the news throws a wrench in the man's carpe-diem lifestyle

House treats a magician who had a heart attack during an illusion. House doesn't like magicians and figures the guy screwed up, but the tests prove otherwise. Meanwhile, the fellows participate in House's newest game: the winner gets immunity and the chance to pick two other fellows, and House will fire one of them.

A documentary film crew is chronicling a teenager with a major facial deformity who opts to undergo a dramatic reconstructive procedure. When the patient suffers a heart attack just prior to the surgery, House and the team are called in to determine the cause, since the surgery cannot proceed until the patient's cardiac condition is diagnosed. With the film crew covering their every move, Cameron and Chase are especially self-conscious, and House looks for ways to escape from the cameras. Meanwhile, House finds himself distracted by several of the candidates vying for a spot on his team, and he questions his motives for having chosen them.

House is recruited by the CIA to help diagnose a deathly ill agent with an unknown illness. The agent's medical case is being spearheaded by Dr. Samira Terzi, who offers up very little information about the agent's history or previous assignments. With limited information to go on, House uses some unorthodox methods to try to crack the code and determine a diagnosis in time to save his mystery patient's life. Meanwhile, Foreman faces resistance from the remaining six fellowship candidates when they question his judgment and argue over the diagnosis of a female drag car racer who passed out after a race

The team takes on the case of a man who collapsed while being mugged. When the man complains of new symptoms that do not fit his initial admission profile, the team suspects he is a hypochondriac. As Mr. X continues to fall ill with symptoms unrelated to his neurological disorder, Foreman and the remaining six fellows are assigned to keep watch, and are bemused as they see their own behavioral idiosyncrasies reflected through him. As they attempt to diagnose this human chameleon, they seem to learn more about themselves than their patient, whose true identity is a mystery. Meanwhile, Cameron and Chase keep a running pool on whom House might cut next from the team of candidates, and Foreman engages in a power struggle with House and Cuddy.

The team treats a patient who not only claims to see the dead, but she communicates with them and knows things about them she normally couldn't find out.

The final 10 candidates are put to the test when House splits them into gender groups. Each team is assigned to accurately diagnose and treat a man with muscular atrophy who is slowly suffocating. Complications arise when one team treats the patient, but doesn't make sure their treatment was executed.

Meanwhile, as the teams work, House conducts experiments on himself to see how it feels and what occurs in the moments when a person is in between life and death.

House reluctantly agrees to interview potential new team members and does so in his own way. He calls in all 40 applicants and places each of them in a Darwinian trial period. As he tests them, and fires some along the way, he is approached by Greta, a NASA training program candidate, who is having neurological issues and begs House to help her in private so she can be accepted into the training program.

House takes Greta's case to his applicants, pitting them against one another as they compete to come up with an accurate diagnosis. Later, House is shocked when he sees what appears to be Cameron, Chase and Foreman in the hospital hallways.

An office building collapses and House must race against the clock to diagnose Megan, a young woman who survived the disaster but can only communicate through blinking. However, House is without a team after Foreman and Cameron quit and the firing of Chase, so he's forced to talk through his ideas with the hospital janitor. But when Megan's condition worsens, House is pressured to hire a new team. Through reluctant to do so, House begins to realize diagnosing patients by himself is not as easy as he thought.

A Cuban couple flee to America to find Dr. Gregory House, as the wife is suffering from undiagnosed illness. However, when they finally get there they find that House can do little for them. Meanwhile, the staff deal with Foreman's departure, which heralds the first of several radical changes in the staff.

Obnoxious 16-year-old chess prodigy Nate is admitted to Princeton-Plainsboro suffering from intense head pain that came on after he attacked his opponent during a speed chess tournament. Nate's mother tells the team that Nate has been having behavior problems ever since he became a teenager, and House suspects the behavior is a symptom of cluster headaches. As House's team carries out further testing to see why he might be having the headaches, Nate manages to offend and annoy each doctor on the team. As Nate's illness progresses, his liver and kidneys begin to fail. To narrow down the list of possible diagnoses, House carries out a series of unconventional and eccentric tests of his own, including engaging Nate in a game of chess to try to beat him at his own game. Meanwhile, Foreman's frustration with House reaches a new level when he believes House sabotaged his job interview with another hospital, and Cuddy makes Foreman an offer she's sure he can't refuse.

Addie, a 19-year-old college student, is admitted to Princeton Plainsboro after coughing up a mouthful of blood during karate class. Before treating the patient, Foreman unapologetically informs the rest of the team that he is resigning, but will not say why.

House strongly believes an infection is to blame for Addie's bleeding, even though her symptoms indicate otherwise. When Addie's lungs suddenly fill with fluid, the team believes that cancer or toxins could be an underlying cause, but House refuses to stray from his initial infection diagnosis. As Addie's condition worsens, House suggests a risky life-or-death treatment to confirm his suspected diagnosis, leaving the team wondering whether he cares more about making a diagnosis than he does about saving Addie's life.

Meanwhile, House takes a special interest in a young, attractive nutritionist named Honey, who accompanied her boyfriend to the clinic for treatment. Knowing he will have a position open soon on his team, House has Honey fill out an employment application and sees to it they meet again under more casual circumstances.

Wilson prepares his 14-year-old leukemia patient, Nick, for a last-resort bone marrow transplant from his younger brother, Matty. With Nick's immune system completely wiped out from chemotherapy, Wilson is extremely cautious about keeping him healthy before the transplant. However, when Matty sneezes during a pre-op visit to his brother, Wilson knows that Matty is not healthy enough to donate. House and the team race to find out what is making Matty sick so that they can treat him quickly and allow him to donate healthy, uninfected bone marrow to his dying brother. With no other matching donors available, the team knows that Matty is their best shot at saving Nick's life, since giving Nick bone marrow from a partial-match donor could lead to an excruciating death if Nick's body rejected it. House decides they must purposefully make Matty sicker and use his developing symptoms as a method of narrowing the diagnosis field. As both brothers' conditions worsen and Nick has only days to live, the team must diagnose and treat Matty before it's too late for both brothers.

Meanwhile, Foreman is haunted by his mistake that killed a patient just one week earlier, and House only wishes he could incur similar misfortune upon his new pet and nemesis, Hector.

The team takes on the case of Lupe, a young female scam artist who passes out while working a card-playing scheme on the streets. Lupe suffers from a lack of blood to the brain which had temporarily paralyzed her ability to make decisions or exercise free will. Measuring from her background, Foreman immediately suspects Lupe's condition stems from drug abuse, while Chase looks for other possibilities, such as toxins, in Lupe's apartment.

Lupe senses Foreman's disdain for the decisions she's made in her life, and Foreman grapples with his own humble past when his parents come to visit him. When Lupe's symptoms worsen and her organs begin to shut down, Foreman and the team suspect cancer to be the culprit.

Meanwhile, Cuddy and Wilson go out on a date to see an art exhibit together, and House probes Wilson's ex-wife about Wilson and his dating habits.

When the team learns some devastating news about Lupe's condition, they realize that their own decisions, rather that Lupe's, may cost Lupe her life.

The team takes on the case of 6-year-old Lucy, who collapsed at daycare. They discover that the tissues surrounding Lucy's heart have hardened and are strangling her heart, a condition usually found in much older patients. As the team searches for an explanation, Lucy's condition worsens and she suffers a stroke.

There's a palpable tension between Cameron and Chase, and House intentionally assigns them tasks to do together, including a trip to Lucy's house to check for any possible environmental explanations for her condition. While there, they discover surprising evidence indicating that Lucy may have been abused.

Lucy's 8-year-old brother develops a not-so-innocent crush on Cameron, and as he becomes increasingly aggressive, House suspects that whatever is killing Lucy has begun to affect her brother, too. As they try to narrow down what is causing Lucy's condition before its too late, House and Cameron clash over how to treat her.

Meanwhile, when Wilson takes Cuddy out to see a play, House puts ideas in Wilson's head regarding Cuddy's motivation for going with him.

House and Cuddy board a flight back to the United States from Singapore, where they were speakers at an international conference. Shortly after takeoff, a passenger seated next to House becomes violently ill. While House brushes it off as a hangover, Cuddy suspects the man might have a deadly contagious virus and the other passengers could be at risk. Assuming the worst, Cuddy suggests the plane turn back and land, but House dissuades the flight attendant and the flight continues on. As the man's condition worsens, the rest of the passengers on the flight become increasingly uneasy, and so does House when a second passenger falls ill with the exact same rash and debilitating symptoms.
Back at Princeton-Plainsboro, Wilson leads the team when they encounter Fran, a middle-aged woman who collapsed at her home and soon goes into seizures. Cameron and Chase investigate Fran's house to look for clues to a diagnosis, but they are distracted by the prospect of an empty house and an inviting bed. When they return empty-handed and Fran's health continues to decline, the team must focus on finding out what is killing Fran without House's help. Back on the flight, with First Class turned into a makeshift isolation area, House calls upon a misfit team of passengers to fill in for his own team, as he bounces questions and theories off of them. When Cuddy collapses and several more passengers fall ill, the situation turns dire as the plane is hours away from any viable landing place. Without the help of his team or even proper medical equipment, House finds himself with Cuddys life and a plane-full of passengers lives in his hands.

A famous, 42-year-old, pregnant photographer, Emma Sloan, is brought to the hospital after suffering a stroke in the middle of a high-profile photo shoot with Tyson Ritter. Although Emma's condition initially stabilizes, her health takes a turn for the worse when her kidneys inexplicably fail. As her health continues to deteriorate, Emma is more concerned about her baby's well-being than her own.

With no other viable explanation for the kidney failure, House realizes Emma may have a rare condition called Maternal Mirror Syndrome, in which the mothers health mimics the distress level of her fetus.

Meanwhile, Cameron and Chases secret relationship is exposed to Foreman and Cuddy, and House makes extravagant plans to take a much-needed vacation.

House calls Cuddy on the fact shes taken a special interest in the case as she identifies with Emma's struggle to have a child later in life, but her compassion for Emma may be clouding her judgment in the case. When Emma's liver begins to fail, House presents her with the heart-wrenching choice to terminate her fetus or die herself. But with Cuddy on her side, Emma demands they come up with another option an option that may not exist. With Cuddy and House at odds over how to handle her case, Emma faces a life-and-death situation for both herself and her unborn child.

House is bewildered yet intrigued when he meets his newest patient, John Kelley, an ex-Marine who had saved Houses life in a very realistic dream the night before. House is puzzled about how this man could have appeared in his dream before he met him.

Recently returned from a two-year deployment in Iraq, Kelley is complaining of fatigue, pain and other non-specific ailments he thinks are the result of Gulf War Syndrome. Just like the V.A. doctors before them, the team is wary about the validity of Kelleys symptoms, but since his uncle is an important benefactor to the hospital, they continue to investigate his case.

Meanwhile, House is suffering from ailments of his own he is unable to urinate, most likely a side effect of his Vicodin abuse, and is sleep-deprived. Unable to concentrated on the case, he eventually turns to Wilson for an under-the-table prescription.

While administering tests in the sleep lab, Cameron and Chase forego their clinical duties when they find each other (and a bed in the sleep lab) much more exciting. A foul infection shows up in Kelleys mouth while Cameron and Chase were supposed to have been on the clock, and his condition only worsens as he begins to lose his hearing, sight and mobility.

A brain scan reveals tumors in Kellys brain that were not there a week earlier when the government doctors at the V.A. examined him. When traces of uranium show up in Kelleys test results, the teams wonders if the government had something to hide,

Patrick Obyedkov, a 35-year-old musical savant, is in the middle of playing a piano concert when he suffers a painful involuntary muscle contraction in his left hand. After Patrick is admitted to Princeton-Plainsboro Hospital with a rare movement disorder, his case attracts the attention of Dr. House. House learns from Patrick’s father, Dr. Obyedkov, that Patrick suffered severe brain damage at age 10 from a bus accident that also killed his mother. House is intrigued as to why Patrick, who was a healthy 10-year-old at the time of his accident with no prior musical training, could. suddenly play the piano flawlessly after suffering a severe injury. He pushes for further testing on Patrick’s brain even though the team has diagnosed him with a simple muscle-contraction problem. While trying to deduce the origin of the brain rewiring responsible for Patrick’s mysterious gift of music, House and his team must stop the deadly bleeding that is quickly threatening his life. Patrick’s condition worsens as he suffers an onset of seizures, and as the team attempts to stabilize him, House presents a very difficult option to Patrick’s father – a neurological procedure that would change Patrick’s life forever. In the meantime, Cameron discovers that House has been in contact with a hospital in Massachusetts and suspects that House may be looking to take a new job there. When Cuddy contacts the hospital, she learns that House has been in contact with a brain cancer specialist – not as a job applicant, but as a patient for a clinical trial. When confronted by his team, House denies the gravity of the situation and resents their interference, and they are forced to contend with the possibility his condition may be more serious than he’s letting on.

Its Valentines Day at Princeton-Plainsboro and the ER is short-staffed due to a snowstorm. House encounters Foremans latest patient, Hannah, who has sustained injuries from a car accident with her mother, Abby. House notices that despite her best efforts to act injured, Hannah is not feeling a bit of pain. House determines that Hannah has an incredibly rare condition that makes her completely insensitive to pain, and he takes a special interest in her case. He orders further testing to see if Hannah has any serious injuries from the car accident that she may not be able to feel, including an unnecessary procedure that causes Cuddy and Wilson to question his motives. Meanwhile, Abby undergoes surgery for her own injuries sustained in the car accident. Hannah refuses further examination and demands to see her mother, but House has little sympathy. She and House argue about which of their lives is worse, Hannah who is impervious to pain or House who suffers from pain constantly. When Hannah passes out and her temperature spikes, the doctors realize that Hannah is much sicker than they had thought. The team takes drastic measures in an attempt to inflict pain on Hannah to measure her pain threshold, but her condition only worsens. House adamantly pushes for a spinal nerve biopsy that could leave her paralyzed, a risky procedure in which few see the benefit, especially Cuddy and Wilson, who accuse House of pushing the test to get information that may benefit his own pain management. As Hannahs body deteriorates without her so much as flinching, House works through his own chronic pain to find out why this young woman cannot feel any pain at all.

16-year-old Stevie Lipa is admitted to Princeton Plainsboro Teaching Hospital with a serious respiratory condition and internal bleeding. Oddities of his case land him under House and the team's care, but at the moment, House is irritated to learn that new hospital researcher Dr. Julie Whitmer has been assigned his handicapped parking spot by the hospital entrance. Since she's in a motorized wheelchair (and he has to walk), he asks her to give up the parking spot, but she refuses. House, determined to get a parking spot closer to the hospital entrance, appeals to Cuddy, who dares him to prove how much he wants the spot by spending one week in a wheelchair, a bet House takes on. As the team tries to get personal history information from Stevie, they can't seem to get a straight answer out of him, and it's revealed he's from a family of gypsies. Stevie's parents arrive with homeopathic remedies; they won't consent to House and the team's suggested course of action, and refuse all modern medical treatment. As Stevie's body continues to bleed internally, Foreman makes the risky decision to sidestep Stevie's parents and appeals directly to the teenage patient, putting his medical license on the line while asking Stevie to lie to his parents.

House has beaten the drug charges and is back at the hospital after a short stint in rehab. Cuddy comes to collect on House's debt for perjuring herself on the stand and keeping him out of jail. She forces House to pay off the debt in clinic hours, requiring him to carry out a series of less-than-desirable patient exams in the clinic. Tired of House's incessant whining about his disdain for the patients, Cuddy turns his clinic duty into a game, with the stakes raised to a level that speaks to House: money. At the clinic, House encounters patient Eve, who has tested positive for an STD and admits she's very recently been raped. Knowing he can't do anything more for Eve medically, House refers her to a psychiatrist, but she refuses to talk to the doctor and will only be treated by House. He repeatedly tries to dismiss himself from her case, but finds himself forced to unravel a very different puzzle than the sort he's used to and is compelled to come to terms with events in his own life in order to help Eve make sense of her own. Meanwhile, at the clinic Cameron encounters a homeless man with terminal cancer who, in spite of her pleas to let her ease his suffering, admits to her his basis for refusing pain medication during his final hours.

House must make a tough decision to avoid going to jail, while a firefighter refuses to reveal the secret that may save his life.

Wilson betrays House to Tritter in the belief that House will finally gets the help he needs. House refuses, and Cuddy is forced to cut off House's Vicodin supply, leaving him unable to deal with a 15-year-old little person who entered the hospital with a collapsed lung and anemia, and whose condition soon deteriorates.

Divorced parents argue over how to treat their daughter, who seemingly has pancreatitis. House takes them to court on behalf of the hospital to force the treatment he believes she needs. Meanwhile, Tritter continues to try and find something against House, and goes to obsessive lengths to do so.

A young man forced to raise his younger siblings has to choose between a necessary medical treatment and keeping his family together. Meanwhile, Tritter goes after Wilson in his quest to bring charges against House.

Gabe, a 10-year coma patient, receives a visit from his son Kyle. When House induces a coma in Kyle, he realizes the boy may be suffering from a genetic condition, and has to turn to Gabe for answers. Meanwhile, Tritter puts pressure on Chase, Cameron, and Foreman to reveal what they know about House's abuse of drugs.

An immensely overweight man is brought in after he's found at home in a coma. Upon regaining consciousness, he demands to be released. When Cameron comes up with a way to force him to stay, the man insists the find a reason for his illness other than his obesity. Meanwhile, Det. Tritter arrests House, searches his home, and questions his co-workers about his Vicodin usage.

A 20-year-old female patient, Tracy Dawson, arrives at the hospital with with breathing difficulties and intense abdominal pain after a robbery. However, her husband starts displaying the same symptoms and the team suspects the couple's illnesses are related. Meanwhile, antagonizing the wrong patient in the clinic.

House sympathizes with a 10-year-old autistic boy who screams loudly for no reason, but his co-workers soon wonder if House empathizes with the boy because he has no social graces either. Meanwhile, House spars with Cuddy over the remodeling of his office, and deals with a teenage crush.

House and the team take on the case of a medical researcher who is suffering from an unidentified debilitating case that proves life-threatening despite the hospital's best efforts. Meanwhile, House is forced to return to using his cane when the new treatment for his leg proves less than successful.

House takes on the case of a 7-year old boy who claims to be the subject of alien abduction and experimentation. Meanwhile, Cuddy and Wilson conspire to convince House that his last diagnosis was incorrect in the hope that he might learn some humility.

House is back to work after his gunshot wounds and insists on dealing with two cases which involve paralysis. However, his life-threatening wounds have left House with a new outlook on life that leave his co-workers suspicious of his motives.

man with giant tounge

Just as House and his team are working on the a man with a giant, swollen tongue, a disgruntled former patient Jack Moriarty walks into House's office and shoots him. House decides he must continue to treat Vince from his ICU hospital bed with Moriarty, shot by hospital security and hand-cuffed to his bed, as his roommate. Soon, the aftereffects of the shooting begin to impact House and he starts to question his own ability to properly diagnose. As Vince's body deteriorates, House must struggle through his self-doubt and trust his team to find a way to solve the case.

House's ex-bandmate brings in a 16 year old girl Katrina victim, whom he recently just found out was his daughter, because she has been suffering hallucinations about the catastrophe. House is convinced the girl is trying to scam his friend and must work through the girl's lies to try and figure out what is truly wrong with her. Meanwhile, House is asked by Cuddy to review two medical files and discovers she is looking for a sperm donor.

After a young mother has a seizure while bathing her child and almost drowns him, House and the team must discover what is causing Kara's seizures and find a way to save her son's life. Soon, both of their conditions worsen and Kara's husband is forced to make a tough decision, but he soon learns a shocking secret about his wife. Meanwhile, Chase decides he needs a break from the hospital and House wants to know why Cuddy has asked Wilson out on a date.

In the conclusion, the police officer has died and Foreman's symptoms continue to get worse. He is now experiencing the same blindness, excruciating pain and muscle contractions that the officer had just before he succumbed to the still unknown disease. As Foreman realizes that he may die, he gets in contact with his father who quickly comes to be at his side. Foreman's condition quickly begins to worsen and the only solution is a brain biopsy. House is determined to find the solution in the dead officer's apartment before Cameron has to do the biopsy on Foreman's brain.

After a police officer is shot and begins experiencing unexplained giddiness, House sends Dr. Foreman to the man's office to see if he can gather a clue as to why he is acting the way he is. Soon the officer's health begins to decline and Foreman suddenly begins to experience the exact same symptoms as the officer. The team must race against time and solve the man's case before Foreman begins to suffer the exact same fate.

House takes the case of a Boyd, a 15 year old faith healer, who thinks he can talk to God. House thinks he's making it up, until he sees Boyd touch one of Wilson's cancer patients and she later goes into remission. After Boyd decides that he will not have brain surgery because he his afraid he will lose communication with God, the entire team must confront their feelings about faith. Meanwhile, Cameron and Foreman are still at odds over the medical article she accused him of stealing.

After a patient, Hannah, is brought after taking an overdose of sleeping pills, it is revealed that she previously had not slept in 10 days. As her condition becomes worse, House discovers that she will need a liver transplant. It turns out that the woman's girlfriend, Max, is the perfect match. However, after the team discovers something else about the couple's relationship, it forces them in an ethical quandary. Meanwhile, Cameron accuses Foreman of stealing a medical article she wrote, but he says he wrote one almost exactly like it before hers was even submitted.

A 6 year boy is brought into the hospital with symptoms that House is convinced he has seen before in an elderly woman who died. House tries to convince Wilson to keep Cuddy from knowing what he is up to as he becomes frustrated in trying to find a way to cure the boy.

Melinda, a rebellious girl, has a severe allergic reaction and ends up going into shock because she is immunocompromised from a heart transplant she had earlier in life. Soon Melinda's condition worsens and she becomes paralyzed, with the paralysis slowly moves up her legs. To make matters worse, her overprotective mother and boyfriend are constantly fighting about her condition. The team must find a way to stop the paralysis and figure out what is wrong with her before it gets to her heart. Meanwhile, House and Wilson are still having problems with their living arrangement.

Bob comes in suffering from a breathing attack after role-playing with his wife. After trying to find out what's wrong with him, House decides to tell the man he has a sexually transmitted disease, which causes his wife to tell House a secret. Meanwhile, Wilson has moved in with House and things are not going too well for either of them.

After man experiences a seizure but has no idea he has had it arrives at the hospital, House eagerly takes on the case. The team believes he has a bacterial infection, but Henry suffers a heart attack before the treatment for his infection is able to work and now needs a heart transplant. He chooses to approach the husband of the deceased woman, and feigns interest, only because he wants the heart. House and the team have to race against time to find out what the woman died of before they can use her heart for Henry.

House must treat a teenage supermodel for her heroin addiction, but soon realizes there is something different about her. Wilson is wondering if House's increased leg pain means that his leg nerves are actually regenerating. Also, a male patient in the clinic is somehow experiencing his wife's pregnancy, including her labor pains.

A young man comes into the hospital severely burned, but the test quickly show that their is something unusual about his blood tests. The team has to get creative to figure out how to test the patient before his body completely shuts down. To make matters worse, House is hellbent on proving that one of his old medical school colleague's new migraine drug does not work no matter what he happens to be saying. So, House decides to make himself the guinea pig for his own batch of tests with some painful results.

A young housewife, who happens to be taking some fertility medication, is brought to the hospital when she begins having muscle spasms so bad that she crashes her car. As Margo's symptoms continue to get worse, House and the team think she might have Huntington's Disease but when Margo descends into paranoia, they dig deeper and discover that she might not be telling them the whole truth. Meanwhile, after House and Stacy return from Baltimore with a rekindled relationship, Wilson begins to worry that House is just setting himself up for a hard fall. Also, Cameron is refusing to find out the results of her HIV test.

After journalist collapses at his editor's retirement party and hits his head, he regains consciousness but his words do not make sense. Since House is in Baltimore trying to defend his Medicaid billings with Stacy, the only way the team can help figure out what's wrong with Fletcher is through the telephone conversations. Meanwhile, as they are stranded at the airport together, House and Stacy realize that they still have feelings for one another.

After a gambler collapses in front of House while they’re both betting on horse races, the team soon discovers she’s been seeing a number of doctors for a variety of supposed illnesses. This leads everyone, but a skeptical House, to believe that it is Munchausen’s which is a disease that causes people to fake symptoms for the medical attention. Of course, with Foreman as House's supervisor, it becomes more difficult for him to get things done his way.

Chase misdiagnoses a woman with an ulcer, and flashbacks dissect the case as her condition deteriorates. Stacy questions him and House about it following the patient's death and prior to a hospital disciplinary hearing.

A scuffle with House lands a gay man with AIDS in the hospital, where he provides the disagreeable diagnostician with a medical puzzle. The man coughs up blood on Cameron, who begins behaving uncharacteristically. Elsewhere, House finds an unusual way to spend time with Stacy.

After a professional bicyclist is brought in, House refuses to treat him because he is convinced the man is lying about using steroids to help him perform better. Cameron is upset at the fact that the man is actually a hero to little kids and ponders what she should ethically do. Meanwhile, House decides to ruin Stacy and Mark’s relationship by attending a group therapy session with Mark.

A recent Princeton graduate ends up in internal shock while attending a frat party. With his father by his side, it's clear that Carnell is not being too truthful about his life. House soon thinks that his symptoms could be caused by a recent Spring Break trip the young man took. Meanwhile, House is actually having his own issues with his father and keeps trying to get out of a dinner engagement with both his parents who have just arrived for a visit.

After Dr. Sebastian Charles, who is renowned physician and head of an international organization to fight the spread of tuberculosis among the poor in Africa, is rushed to the hospital after collapsing, he immediately determines all the symptoms are from TB. House does not believe it and orders rounds of tests. Soon after the case gets the attention of the media, Dr. Charles refuses any more tests and medication in order to bring to light about the medical needs in Africa. Cameron actually sees eye to eye with Dr. Charles, but House ends up making his situation worse. Meanwhile, Foreman fills in for House in the clinic with mixed results.

Cuddy's young handyman, Alfredo, ends up falling from her roof and she soon joins the team in figuring out what caused him to fall in the first place. Cuddy is racked with guilt, even more so after House must amputate his hand after it becomes infected, because he is the sole provider for his family. After taking a trip to his neighborhood, the team may figure out just what caused Alfredo's illness in the first place.

A young girl who suffers from cancer is about to administer her medicine when she begins hallucinating. An ill House shows up to work and Wilson asks him for help on the case. The doctors learn that the hallucinations are unrelated to the patient's cancer. After numerous tests, the doctors can find nothing wrong with the young girl. However, House believes that the girl's bravery is a symptom of a dangerous disease.

An inmate on death row starts seeing hallucinations of the people he has murdered. Cuddy reluctantly offers a very excited House the case. Without a respirator the inmate will die within an hour. Stacy pulls some strings and the inmate is brought to the hospital, where House's team of doctors couldn't care less about treating a man who will die anyway. Meanwhile, Cameron is having trouble telling a patient that she has cancer and will soon die.

House is convinced that just because Stacy married someone else, he can handle treating her husband. However, when Mark's tests come back normal, House is stumped as to why all the symptoms show that his brain is still dying. Wilson worries about his friend's emotional well-being and the entire team wonders if he can put his feelings for Stacy aside long enough to find out what's really wrong with Mark. Cuddy ends up adding to the dilemma when she ends up offering Stacy a reason to stay.

House is surprised when his ex-girlfriend, Stacy Warner, makes a visit. He's even more surprised when he finds out that she's not there to see him, but to get help for her ailing husband. As House debates over whether or not to take the case, Cuddy decides to make him a substitute lecturer to a class of medical students. While there, he weaves together three stories of patients who all have the same symptom. The lecture is one that the students, and all those who hear it, will never forget.

House apparently finds a way to scare one of the clinic patients into having a stroke. Soon the team is trying to find their way through the patient's odd lifestyle, an overbearing "friend" and reluctant parents in order to stop the strokes and try to save the guy's life. Meanwhile, the hospital is abuzz with House's upcoming date with Cameron, so Chase, Cuddy, Foreman and Wilson all try to give him and Cameron advice.

After a meningitis outbreak hits the hospital, House decides to focus on a 12-year-old whose symptoms are similar to the disease. House, Foreman and Chase must devise ingenious ways and locations to treat the girl's delicate condition amid the chaos, even though Cuddy only gives them an hour. In the meantime, House decides to ask Cameron to come back to her job now that Vogler has left. She agrees, but on one surprising condition.

House and his team are trying to find out discover just what is causing brain and kidney dysfunction in a pregnant woman. After House finally diagnoses his the woman's illness, she and her husband must chose whether to save her life or that of their unborn child. Meanwhile, Vogler sets up a board meeting to get rid of House, but when Wilson refuses to make the vote a unanimous one, Vogler lashes out against him and shocks Cuddy and the rest of the board with his decision.

After Senator Wright become ill at a fundraiser, Vogler convince House to take Wright's case. To save his whole team, House must deliver a speech on behalf of Vogler's pharmaceutical company, which he does. However, it's certainly not the speech Vogler wanted him to give. Meanwhile, after the Senator's symptoms and tests point to AIDS, a condition which would end his hope of becoming the President, House and the team dig for different answers.

An obese 10-year-old girl presents with a heart attack. At first thinking it's an adverse reaction to diet pills, they ultimately uncover a much more deadly source of her illness. Also, House is also faced with a woman who will not accept a surgery for a 30 lb. tumor because she actually wants to remain overweight. Meanwhile, House is under orders from Vogler to fire one of his team. He finally makes a decision but Vogler doesn't accept it and demands he pick someone else, it leads House to suspect one of his own team members is giving inside information to Vogler.

Moments before mobster Joey Arnello is set to reveal his mob secrets in federal court, he ends up collapsing. A court order instructs House to find out if he is faking and quickly. House and his team struggle to diagnose and cure Joey mainly because his brother, Bill, is dead set against Joey testifying at all. In the meantime, Cuddy tries to convince a disbelieving Vogler that House is actually an essential part of the hospital and not just costly as he thinks. Joey keeps mysteriously slipping in and out of a coma and now that his job is on the line, House decides it's time to make an exception to his own policy and tries to get to know his patient.

The hospital is turned upside-down when billionaire entrepreneur Edward Vogel ends up buying his way into becoming Chairman of the Board. Vogler sees the new job as a way of making the hospital a new biotech venture. This means that they would no longer need the services of Dr. Gregory House. Meanwhile, a powerful young woman ends up paralyzed for no reason that anyone can explain. Soon House is on to her deadly secret, but he wonders if he will be on the job long enough to save her life which could end up costing him his medical license.

After a 12 year old boy is convinced he is cursed because a Ouija board revealed to him that he is going to die soon, his father, who just so happens to be major financial supporter of the hospital, makes unbelievable demands of House and his team as they struggle to find a diagnosis for his symptoms, which include a rash and a week long fever. Chase becomes outraged when House invites his father from Australia to help him with his diagnosis. House is shocked to see that Chase and his father are not close at all. After House finally diagnoses him, the boy begins to believe that his father might not be so truthful after all.

Although baseball player, Hank Wiggen thinks he just has a badly broken arm, it turns out he has some severe bone loss and his career is over. Soon, House believes that Hank is using steroids, even though he swears he has not. Hank's kidneys begin to fail and his wife says she will gladly donate one of hers, but if she does she will have to abort her still early pregnancy. Hank, after hearing this, tries to kill himself. It's up to House and his team find out what the true problem is and soon if this pitcher's life, as well his career, is going to be saved. Meanwhile, Foreman dates a pharameutical rep and House ends up getting stuck with two tickets to a monster truck rally and ends up going on a "date" with Cameron.

House decides to take Cuddy's challenge and stops taking Vicodin for a week in exchange for no clinic duty for a month. House's withdrawal symptoms become more and more severe as he and his team have figure out why a 16 year old girl will not stop bleeding after being in a car accident. Foreman and Cameron begin wondering if House is stable enough to even be attending this patient.

Dr. Foreman is convinced that a homeless woman is faking seizures just so she can get a free meal. However, Dr. Wilson determined to keep her from falling between the cracks of the system. Soon, her symptoms actually do get worse and House and his team feel that getting an accurate history of the patient will be the key to solving the mystery. Foreman believes that she has contagious meningitis, but when he goes to tell her she has disappeared. She soon returns, after being Tasered by police, which ends up giving House a clue to the real diagnosis. Meanwhile, House is supposed to be helping two med students with their case studies, but chooses to blow the off with mixed results.

After jazz musician John Henry Giles checks into Princeton Plainsboro Teaching Hospital believing he's dying from ALS, he signs a DNR to avoid a slow death. House disagrees with the diagnosis then violates the man's DNR to save his life. House ends up in court and the man's paralysis ends up getting worse. Soon though, the man begins to get better for no reason, leading the team to ponder how this is occurring. Meanwhile, Dr. Foreman meets with an old friend who ends up offering him a West Coast partnership and he might just take him up on the offer.

A young high school male comes in to the hospital with a lethal poisoning, but neither House or the rest of his team can find out what has caused it. House decides to send Cameron and Chase to the teen's home to find the hot new drug House is sure he's taking. They don't find drugs, but do find something that would explain his symptoms. That is until another student comes in with the exact same symptoms. Meanwhile, an 82-year-old patient becomes obsessed with House who is trying to figure out the basis of her renewed fascination with her sexual feelings.

After a husband finds his wife in bed and cannot wake her up, he rushes her to the clinic. Puzzled by her symptoms, they consider everything from cancer to rabbit fever. When all the treatments fail, House comes up with the diagnosis of African sleeping sickness. The woman will die without the proper treatment but neither she nor her husband admit to having an affair because the only way she could have contracted the disease was through sex.

Lucy Palermo is a schizophrenic mom with deep vein thrombosis and also displays mixed symptoms, including a tumor, but House realizes her cannot figure out what is wrong with her. After an anonymous call to Social Services, House begins to question whether Lucy is really schizophrenic, and causes her son, Lucas, to blame Dr. House for making the call which will take him away from her. House decides to then take Lucy off all her medication and then secretly sends Foreman and Chase to search her apartment for clues. All of this happens on House's birthday which he is trying to forget, but no one will let him.

House has a new patient whose hands are red with boils. She is a nun and all of her fellow nuns believe her condition to be stigmata. After what seems to be an allergic reaction to the medicine House prescribes, Cuddy orders him to research the case. During an MRI, the nun starts to suffer from convulsions. House wonders if her past is coming back to haunt her, as the doctors provide different theories about the nun's condition. However, only one of them has the correct answer.

After two newborns in Princeton Plainsboro's maternity ward fall ill, House takes on the case. Soon the illness has spread to six babies, all of which have high fevers and low blood pressure which could mean that these newborns will die in less than a day. House wants to test which medicine works better, by putting one of the babies on a different medicine, despite the fact that this experiment may have a fatal effect, which angers Dr. Cameron and the rest of the specialists.

Brandon is 22-year old male, who ends up passing out after having rowdy sex with his fiancée. He complains of abdominal pain, nausea and suffers from fever and low blood pressure. House and Foreman test out their theories however after a dangerous drop in white blood cells they must find a solution and soon. After Wilson keeps nagging House about his nasty pill habit it proves extremely useful to House about Brandon's situation. Meanwhile in the clinic, House must deal with a boy and an unusual situtation involving a MP3 player.

A 16 year old patient comes in suffering from double vision and night terrors. House dismisses the kid but as he's leaving the hospital the patient suffers from myoclonic jerks. House thinks that the patient may be suffering from Multiple Sclerosis, but the night terror hallucinations disprove the diagnosis. As he gets worse, Cuddy is horrified at the fact that House is making bets on the child's paternity, which might be the key to solving the case. Meanwhile in the clinic, House is having to deal with a man who is trying to set up a lawsuit and a mother who refuses to give her baby vaccinations.

A young teacher suffers from seizures in front of her class of kindergartners. She is taken to Princeton Hospital, where a world renowned doctor, Dr. Gregory House is assigned to her case. With his team of young doctors, House finds a tumor within the teacher and it turns out that she hardly has any time to live.