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Laverne and Shirley is a situational comedy television show that follows the trials and antics of brewery workers Laverne Defazio and Shirely Feeney. The show takes place in Milwaukee, Wisconsin in the 1950s. In the later seasons, the two roommates move to California in the early 1960s.

Laverne is the daughter of an Italian pizzeria owner and is originally from New York. She is outgoing and tomboyish. Shirley, on the other hand, tries her best to be a refined lady, even though she acts more like a little girl who dreams of marriage and kids. The personality differences between the two fuel much of the comedy of the show, which mostly follows the two working-class women's love lives and their interactions with their friends, family, and neighbors.

Recurring characters include the title women's eccentric neighbors, Lenny and Squiggy, who often flirt with the girls but are always rejected. Carmine Ragusa, Shirley's occasional boyfriend, appears in many episodes also. Edna Babish, their landlady, and Laverne's father, Frank, also make regular appearances, and eventually the two get married and move to California with Laverne and Shirley.