Many years after the tragic events of the first Firestarter film, Charlie McGee remains on the run from her past. On the road under an assumed name, she lands a job at a university library where she secretly researches to find a way to suppress her pyrokinetic abilities. At the same time, a man named Vincent works for a large influential research firm looking for people involved in a mysterious 1970s experiment as part of a supposed legal settlement. In truth, the corporation is killing off these people to eliminate evidence of past wrongdoing. Eventually, he locates the most elusive product of the experiment - Charlie McGee. Together the two uncover the scheme at the corporation and must work together to stop it. On the way, McGee discovers that her nemesis John Rainbird is still alive, and that he has a new group of charges - several boys with their own special abilities.