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A new hotshot doctor arrives at Chicago Med causing competition for Dr. Rhodes. Dr. Halstead and Dr. Manning work together to diagnose a Syrian refugee without a medical record. When Robin is admitted back into the hospital for more complications, Dr. Reese takes a different approach to her treatment. Distracted from work because of Robin's worsening case, Dr. Charles is challenged by Goodwin and Noah hosts a graduation party that brings everyone together.

Dr. Rhodes challenges Dr. Charles and other hospital staff over the proper treatment for Robin. Dr. Manning seeks help from Det. Halstead when a sensitive case involving a young girl turns into a crime. Dr. Choi and April work together on a conflicting case. Meanwhile, Goodwin helps a friend in distress and, after eagerly awaiting, the doctors are surprised to learn who the new med resident is when match day finally arrives.

Dr. Rhodes is desperate to save a mother who is on a quest to help her daughter beat cancer. Dr. Charles asks Sarah to conduct his daughter Robin's psych evaluation but has difficulty staying out of the case.

Things get personal for Dr. Halstead when his unsupportive father receives medical attention despite his refusal. When treating Will's father, Dr. Rhodes reflects on his relationship with his dad.

A hacker demanding a ransom payment locks the hospital computer system, forcing the doctors to rely on their own knowledge while treating patients. Feeling overwhelmed, Goodwin struggles to keep the hospital afloat when an unexpected visit from her ex-husband Bert and his new girlfriend worsen the situation.

Will is faced with a moral dilemma when his former teacher, Dr. Bella Rowan, is faced with a life-threatening disease. Dr. Rhodes and Dr. Bardovi get involved in a sensitive situation when Rhodes disagrees with the father of a young patient regarding a risky procedure.

Dr. Choi and Dr. Halstead argue over how to treat a patient with stroke symptoms while Dr. Manning tends to a young boy who fell in the river and witnesses the effect it has on his family. Meanwhile, the staff deals with the suicide of one of their own.

A troubled teen in a psychiatric facility reaches out to Dr. Reese and Dr. Manning to help guide the parents of a comatose girl who is pregnant.

When a trauma patient survives the ride to the hospital, Dr. Rhodes is determined to keep the man alive. Dr. Choi and Dr. Manning struggle to locate the infection in a paralyzed patient. Dr. Reese must find purpose for a grieving widower who relies on a superhero costume.

The staff prepares for an influx of patients after an early morning pileup caused by a storm.

Dr. Rhodes convinces Dr. Latham to join him for a medical trip out of town, which puts Latham's personality issues to the test. Dr. Manning treats an 8 year-old cancer patient who wants to give up on his battle until she makes a surprise discovery. Elsewhere, an unhealthy woman with heart problems is brought in and doesn't want to listen to doctors, much to the dismay of Dr. Halstead. Meanwhile, Dr. Choi, Dr. Charles and Dr. Reese work on a complicated case involving a woman with a personality disorder. Will and Nina work through their first relationship test.

Dr. Manning and Dr. Charles treat a teenage girl who has ever-changing symptoms that have everyone baffled. Dr. Choi and medical student Jeff Clark tend to a 19 year-old tough guy who is brought into the hospital in major distress.

It's a long graveyard shift for Dr. Reese, who must pronounce multiple patients dead. When April gets called in to work, Tate gets upset and encourages her to slow down. Meanwhile, Dr. Charles passes along some vital news to Dr. Latham, and Goodwin asks Dr. Rhodes to work on a most unusual patient.

Dr. Rhodes and Dr. Charles' heart transplant patient gets into an automobile accident, thus complicating her surgery. Maggie's past catches up to her. Elsewhere, Dr. Manning and Dr. Halstead must defend their actions when explaining a patient's cause of death.

Dr. Charles must determine if a patient is a candidate for a new heart, while Jeff makes a confession to Dr. Manning. Dr. Choi deals with two MMA fighters who are brought into Chicago Med in bad shape.

Dr. Halstead and Dr. Manning deal with two feuding brothers who are forced to meet together when one finds himself desperate for a new kidney. Dr. Rhodes and Dr. Latham treat a teenage girl with a genetic condition in need of surgery, but whose overprotective mother is rejecting the course of action.

Sharon Goodwin sees her childhood sweetheart and he's desperate for help. In order to get his financial footing, Dr. Halstead is tempted by a concierge doctor app idea. Meanwhile, a young woman with a heart infection is treated by Dr. Rhodes against Dr. Charles' advice.

Dr. Manning takes care of a young cancer patient but can't find the right words to tell her parents the truth of her condition. Elsewhere, Dr. Reese gets contacted by Danny, the troubled young man, and turns to Dr. Charles and Det. Lindsay for help in resolving a difficult situation.

A car accident during the Chicago Marathon leaves a victim in critical condition and puts Dr. Halstead, April and her fourth-year medical resident brother Noah, to the test when they're forced to perform a difficult procedure in the field. A mother brings in her 8-year-old girl who is complaining of sudden hearing loss.

When several patients have the same rare infection, Dr. Charles' daughter Robyn, an epidemiologist, must find the common link. Dr. Choi and Dr. Rhodes tend to an elderly man who is very ill, but his son and his young girlfriend fail to agree on how to best treat him.

Dr. Manning and fourth-year medical student Jeff Clarke face a language barrier and a mystery illness when an Indonesian man arrives at the hospital with severe symptoms. Maggie takes Dr. Halstead to her family reunion where he meets her sister Denise and uncovers deep-rooted family secrets.

Dr. Manning and Dr. Rhodes discover the ailments of their respective pediatric patients may actually be intertwined. Elsewhere, Dr. Halstead and Dr. Charles treat a homeless man who possesses a positive outlook on life.

In the second season premiere, Dr. Rhodes starts his fellowship in cardiothoracic surgery, but clashes with his new boss, Dr. Latham. Dr. Choi finds it difficult to be the new chief resident, while Dr. Charles approaches Sarah with an interesting opportunity that surprises her.